Bioinspired Chemical Engineering Lab

Welcome to the Tietze Lab

Dr. Alesia A. Tietze,  Associate Professor in Medicinal Chemistry, focuses on bioinspired chemical engineering  of peptide-based molecules/ materials towards diagnostics and drug delivery. My research team develops novel approaches with a goal of providing access to highly hydrophobic peptides/peptide mimetics, i.e. transmembrane peptides/proteins and venom-derived cysteine-rich peptides. We develop novel conjugation methods, explore SAR properties of novel bioactive peptides, and engineer peptide-based nanosensors.

We are located at the Department of Chemistry and Molecular Biology at the University of Gothenburg, Sweden and are part of the Wallenberg Centre for Molecular and Translational Medicine


26/01/2021 - Alesia is awarded Docentship in Medicinal Chemistry at the Faculty of Science/ University of Gothenburg

01/2021 - Alesia is elected to department council at the Department of Chemistry and Molecular Biology/ UGOT

01/2021 - gratulations to Andreas, our paper on NCL of hydrophobic peptides is now online at Journal of Organic Chemistry

12/2020 - our innovation Biosense project awarded with GU Innovation VFT+ Funds (SEK 400,000). Biosense was selected to receive Vinnova’s VFT+ funds managed by GU Innovation for verification activities towards partners, customers and investors.

10/2020 - Alesia awarded with prestigious Swedish Research Council Starting Grant 2021-24 (SEK 3,8 Mio.)

10/2020 - Alesia was inaugurated to the Early Career Advisory Board of Chemistry - A European Journal

09/2020 - Shitanshu joined our group as PhD student, his project focuses on engineering of bioinspired nanopores

08/2020 - Warm welcome to our new members, Karan and Luisa, who are starting their projects as master students. Karan will focus on structure-activity relationship studies of toxins and Luisa on antimicrobial peptides (CARe project)

07/2020 - Welcome Helal and Farnaz! They joined our group starting PhD project and Master Thesis respectively

09/04/2020 - Gratulations to Andreas! He defended his Dissertation in Darmstadt!

March 2020 -  2 PhD positions are available in our group (deadline for applications is expired).

28/02/2020 - Gratulations to Lena! She defended her Dissertation in Darmstadt!

January 2020 We received co-financial support from our CMB department for PhD position in our project "Design and Synthesis of Switchable Peptide-based Nanopores"

January 2020 We received funding from  Centre for Anthibiotic Resistance Research (CARe) research proposals call 2020-2022 for our research grant proposal "Genome-based natural product discovery: Characterization of bioactive compounds in marine Actinobacteria", collaboration with Carl-Johan Wallentin (CMB, GU), Edward Moore (Sahlgrenska Academy/GU), Roger Karlsson  (Sahlgrenska University Hospital) and Beatriz Cámara (Federico Santa María University/ Valparaíso, Chile

25-26/09/2019 Lena is representing our group at the last iNAPO retreat with a talk in Graselenbaach

25-26/09/2019 Alesia is joining 2nd Swedish Medicinal Chemistry Symposium in Stockholm as invited speaker

19-20/09/2019 our team was participating at WCMTM (Wallenberg Centre of Molecular and Translational Medicine) Kick-off on September 19-20 2019

09/2019 warm welcome to Helal who joined our group for Master Thesis within the project of development of peptide-based antivirulence compounds

08/2019 Back from the official visit of Belgorod National Research University/ Belgorod/ Russia after successful measurements of delivered peptides and project discussions

from left to right: Dr. Michail Korokin (docent of Pharmacology and Clinical Pharmacology Department), Dr. Daniel Tietze, Alesia, Prof. Igor Konstantinov (Vice Rector of science), Prof. Michael Pokrovskii (head of the institute of pharmacology on living organisms)

06/2019 Welcome to new team members Hanna, Jie both as PostDocs and Daniel as Researcher in our lab

30/05/2019 finally our lab moved from Darmstadt to Gothenburg! Thank to all who helped us to pack and unpack, special thanks to Lena, Andreas, Ivana, Jie, Hanna and Daniel as well as the moving company to safe and in-time delivery.

January 2019  Postdoc positions are available in our group: Deadline 17/01/2019.

12/2018 LOEWE Project "iNAPO - Ion-conducting nanopores" will be prolonged for a final funding period relied on media report (with Lena's foto on the cover page)

10/2018 Alesia has accepted an appointment as Associate Senior Lecturer in Medicinal Chemistry at Wallenberg Centre for Molecular and Translational Medicine, Department of Chemistry and Molecular Biology at the University of Gothenburg, Göteborg, Sweden and received generous career package from Wallenberg Centre for Molecular and Translational Medicine (ca. SEK 22 Mio.)

09/2018  Poster Prize at the 35th European Peptide Symposium in Dublin, Ireland Our lab’s research on membrane proteins and the development of a conjugation strategy towards quantitative synthesis of these structures gained great interest at the 35th EPS 27.08-31.08.2018 in Dublin, Ireland. Lena was awarded one of the three Wiley Poster Prizes (200 €) for her poster presentation, congratulations! 

07/2018  Gratulations to Lena! She won „Best Talk Award“ at the PhD student day of the chemistry department of the TU Darmstadt on June 28th

01/2018  Our new manuscript about the synthesis of membrane proteins has been accepted for Publishing in Chemical Science: Chemical synthesis of membrane proteins by native chemical ligation: a model study on the influenza virus B proton channel, Baumruck, A. C., Tietze, D., Steinacker, L. K., Tietze A. A.*, 2018, DOI: 10.1039/C8SC00004B 

06/2017  Our new manuscript about some intriguing properties of ILs has just been accepted for publishing in JOC: Reactions of sulfur-containing organic compounds and peptides in 1-ethyl-3-methyl-imidazolium acetate, Baumruck, A. C.,Tietze, D., Stark, A.; Tietze, A. A.*“

03/2017  Alesia is appointed as TU Darmstadt Athene Young Investigator

02/2017  Andreas was a selected participant at the Winter School on Ionic Liquids (within COST CM1206) on February 7 – 10, 2017 in Porto, Portugal. The main goal of this school was to deliver a cross-disciplinary learning approach and condensed overview in the field of ionic liquids with emphasis on State of the Art, R&D methodologies, functionalities and applications. The lectures were problem-solving oriented emphasizing case studies of relevance to properties, characteristics of the ionic liquids and are specially geared towards novice scientists in the ILs field.

12/2016  Subtype-specfic block of voltage-gated K+ channels by µ-conopeptides, Biochemical and Biophysical Research Communications, is accepted for publication

07/2016  We warmly welcome our new PhD studentLena Steinacker to our research group!  06/2016  Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels, BBA General Subjects, is published

05/2016  Positive Evaluation of the Liebig-Fellowship. It is prolonged for the next funding period

01/2016  We are participating in the LOEWE Program for Scientific and Economic Excellence iNAPO (Ion-conducting Nanopores)