Chemical synthesis of bioactive peptides &  membrane-associated proteins: from drug discovery to bioinspired materials

elcome to the Tietze Lab

Dr. Alesia A. Tietze, Assosiate Senior Lecturer (Assistant Professor) in Medicinal Chemistry with focus on total synthesis of bioactive peptides, i.e. cysteine-rich peptides, which are derived from biologically-active  natural sources (i.e. cone snails, spiders, snakes), their targets (membrane proteins) and their structural analogues as well as engineering of bioispired materials based on functional peptides/proteins and artificial carriers (i.e.      nanopores, polymers).


We are located at the Department of Chemistry and Molecular Biology at the University of Gothenburg, Sweden and are part of the Wallenberg Centre for Molecular and Translational Medicine


 06/2019 Welcome to new team members Hanna, Jie both as PostDocs and Daniel as Researcher in our lab

30/05/2019 finally our lab moved from Darmstadt to Gothenburg! Thank to all who helped us to pack and unpack, special thanks to Lena, Andreas, Ivana, Jie, Hanna and Daniel as well as the moving company to safe and in-time delivery.

January 2019  Postdoc positions are available in our group: Deadline 17/01/2019.

12/2018 LOEWE Project "iNAPO - Ion-conducting nanopores" will be prolonged for a final funding period relied on media report (with Lena's foto on the cover page)

10/2018 Alesia has accepted an appointment as Associate Senior Lecturer in Medicinal Chemistry at Wallenberg Centre for Molecular and Translational Medicine, Department of Chemistry and Molecular Biology at the University of Gothenburg, Göteborg, Sweden

09/2018  Poster Prize at the 35th European Peptide Symposium in Dublin, Ireland Our lab’s research on membrane proteins and the development of a conjugation strategy towards quantitative synthesis of these structures gained great interest at the 35th EPS 27.08-31.08.2018 in Dublin, Ireland. Lena was awarded one of the three Wiley Poster Prizes (200 €) for her poster presentation, congratulations! 

07/2018  Gratulations to Lena! She won „Best Talk Award“ at the PhD student day of the chemistry department of the TU Darmstadt on June 28th

01/2018  Our new manuscript about the synthesis of membrane proteins has been accepted for Publishing in Chemical Science: Chemical synthesis of membrane proteins by native chemical ligation: a model study on the influenza virus B proton channel, Baumruck, A. C., Tietze, D., Steinacker, L. K., Tietze A. A.*, 2018, DOI: 10.1039/C8SC00004B 

06/2017  Our new manuscript about some intriguing properties of ILs has just been accepted for publishing in JOC: Reactions of sulfur-containing organic compounds and peptides in 1-ethyl-3-methyl-imidazolium acetate, Baumruck, A. C.,Tietze, D., Stark, A.; Tietze, A. A.*“

03/2017  Alesia is appointed as TU Darmstadt Athene Young Investigator

02/2017  Andreas was a selected participant at the Winter School on Ionic Liquids (within COST CM1206) on February 7 – 10, 2017 in Porto, Portugal. The main goal of this school was to deliver a cross-disciplinary learning approach and condensed overview in the field of ionic liquids with emphasis on State of the Art, R&D methodologies, functionalities and applications. The lectures were problem-solving oriented emphasizing case studies of relevance to properties, characteristics of the ionic liquids and are specially geared towards novice scientists in the ILs field.

12/2016  Subtype-specfic block of voltage-gated K+ channels by µ-conopeptides, Biochemical and Biophysical Research Communications, is accepted for publication

07/2016  We warmly welcome our new PhD studentLena Steinacker to our research group!  06/2016  Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels, BBA General Subjects, is published

05/2016  Positive Evaluation of the Liebig-Fellowship. It is prolonged for the next funding period

01/2016  We are participating in the LOEWE Program for Scientific and Economic Excellence iNAPO (Ion-conducting Nanopores)