Welcome to the Tietze Lab

Dr. Alesia A. Tietze, Professor of Medicinal Chemistry, is dedicated to advancing bioinspired chemical engineering for the development of peptide-based molecules and materials. Her team focuses on creating innovative solutions for diagnostics and targeted drug delivery.

The lab specializes in:

• Designing strategies to access highly hydrophobic peptides and peptide mimetics, including transmembrane peptides/proteins and venom-derived cysteine-rich peptides.
• Developing novel conjugation methods to enhance targeted delivery.
• Investigating the structure-activity relationships (SAR) of new bioactive peptides with antivirulent and bactericidal properties.
• Engineering nanopore-based sensors functionalized with peptides for advanced diagnostics.                                                                      
  

 Through this work, TIETZE LAB aims to unlock new possibilities in therapeutic delivery and biosensing.

We are located at the Department of Chemistry and Molecular Biology at the University of Gothenburg, Sweden and are part of the Wallenberg Centre for Molecular and Translational Medicine

News

2025

February -  we welcome Priyanka Mehra to our team, who will work on Biosense project, incorporating Machine Learning and AI to the sample analysis pipeline

23-28 February -  we have attended Gordon Research Conference on Antimicrobial Peptides/ Ventura/USA, Luisa presented her poster "Nature-inspired unique antimicrobial peptides from Chilean marine sediments" and Alesia's poster "Peptidomimetics as Pan-Sortase A Inhibitors to Treat Antibiotic Resistant Bacterial Infections" was upgrated to a talk in the Late Breaking Topics session chaired by Robert Hancock/University of British Columbia/Canada

2024

1 November - Helal has successfully defended his PhD thesis ”Toward the synthesis and characterization of bioactive peptides: Engineering of transmembrane peptide conjugates for targeted drug delivery”. Congratulations!

January

18 January - Alesia presented lab's research at the GDCh Kolloquium at the University of Rostock, thanks to Prof. Dr. Peter Huy for inviting me. It was very dense and busy day of meeting leading Professors from the University as well as Frauenhofer IZI I enjoyed so much.

2023

December

Very pleased to announce that we have received WALP Proof of Concept funding from Knut och Wallenberg Foundation (3 Mio SEK) and are very excited to speed up developments in Nanopore-based platform for ultrasensitive analyte detection

We are happy to welcome our new team member Dr. Ivan Unksov, as a PostDoc to our Nanopore-based Sensor development project

A warm welcome to Dr. Enoch Appiah who joined our lab for PostDoc to pursue an innovative approach to targeted cancer therapy

Luisa completed her half-time PhD seminar on the 6th of October 2023, half-way to completion of her PhD. Congratulations!

Finally, we moved our lab to the new research building called "Natrium". It is a fantastic place and we love it! Alesia gave a talk on the inauguration of the building on the 17th of November!

Within the framework of a MSc project or internship (advertisement), we are seeking a motivated student to join our Antivirulence/ Antimicrobial resistance Team!

Open postdoc position available in our Lab! https://lnkd.in/eMp7ecue 

Helal at IOPC 2023

Helal just won the "best-poster award" at IOPC. Another great success for the Tietze-Lab!

Alesia was nominated and selected to give a talk on the Young Investigator Workshop, which is the hallmark event of the EuChemS Division of Organic Chemistry on 7-8 July 2023 in Leven/Belgium and ACS Fall meeting in San Fransisco/USA on 13-17 August 2023, the travel is sponsored by Swedish Chemical Society, EuChemS and ACS.

Just got our new paper accepted in Chemical Science highlighting our achievements to combat S. aureus through antivirulent petidomimetics! https://doi.org/10.1039/D3SC01209C

Jordi at TOKS 2023 in Odense, Denmark

Jordi was selected to present one of three snapshot talks during the European Peptide Synthesis Conference on 28 February -2 March in Leeds, UK

Congratulations Jordi on your "best poster award" at the WCMTM Open Event in March 2023. Tough competition!

3-4 February  - Jordi gave a talk on substrate-derived Sortase A inhibitors at the TOKS 2023 conference in Odense, Denmark.

2022

November 2022 - we are happy and grateful for receiving funding from Cancerfonden for the project focussing on targeting cancer by transmembrane peptide-ionic liquids conjugates

October 2022: congratulations to Luisa for receiving funding for her project on the discovery of new antimicrobial peptides from marine actinobacteria from Adlerbertska Stiftelsen

21 October and 27 October - Helal and Shitanshu gave their PhD mid-term presentations. Congratulations! Half-way to go!

19-20 October  - Hanna and Jordi participated in the annual NANION users meeting in Munich, Germany

14 October - Daniel and Luisa participated in the Swedish NMR meeting 2022 in Göteborg, Sweden, Daniel gave a talk about substrate binding and protonation states at the active site of the Ni-SOD-derived metallopeptide

September 2022:

Hanna spent one week with our collaboration partner Gerhard Thiel's Lab at the TU Darmstadt, Germany to gain more experience in measuring our synthetic transmembrane proteins in a lipid planar bilayer

Luisa was selected and participated in a two weeks course "Integrative Structural Biology" organized by InfraLife and hosted by three large research infrastructures in Sweden: SciLifeLab, European Spallation Source ERIC and MAX IV Laboratory. This course included visiting research facilities in Lund, Göteborg and Stockholm

Alesia participated in the 36th European Peptide Symposium which gathered more than 750 peptide scientists from all over the world in Sitges/Spain as a National Representative of the European Peptide Society

June 2022 - a warm welcome to Jordi Hintzen who just joined our team as a PostDoc and his project will focus on the development of protein-based nanopores

June 2022 - Alesia has been appointed as the National Representative of Sweden at the Council (General Assembly) of the European Peptide Society for the 2022-2026 term

30-31 June 2022 - Luisa gave an amazing talk at a CARE meeting about the "Discovery of antimicrobial peptides from marine actinobacteria"

5-8 May 2022 Aarhus/Denmark: Alesia attends Wilson Aarhus 2022, where the latest clinical and translational research in Wilson disease will be represented. Alesia gives a talk on "Ion Conducting Peptide-Based Nanopores as a Powerful Sensing Tool - Ultrasensitive Detection of Bioavailable Cu(II)"

4-5 May 2022 Uppsala: Luisa and Daniel are attending the 3rd NMR Uppsala Minisymposium with talks "Structure determination of new antimicrobial peptides from marine actinobacteria" and "Substrate binding and protonation states at the active-site of a nickel superoxide dismutase-derived metallopeptide: implications for the mechanism of superoxide degradation"

3-5 May 2022 Ystad Saltsjöbad, Ystad: Alesia attends the 5th Annual National Molecular Medicine Fellows 2022 meeting, so thrilled to meet all Wallenberg Centre Fellows from Sweden after pandemics

27-28 April 2022 - Alesia attended 3rd Swedish Medicinal Chemistry symposium with the poster contribution on " Chemical synthesis of transmembrane proteins: from ion channels to bio-inspired sensors".

10 March 2022 - we all attended "Hybrid WCMTM yearly event: Where research meets data science" and won Poster Award. Congratulations!

2021

2-3/12/2021 - Leadership training with Lars Rokkjær (Equilibrio) in Hällsnäs/ Mölnlycke.

Two days of intense professional leadership training with Lars Rokkjær (Equilibrio) for WCMTM fellows (on photo: Cristina Maglio, Fredrik Sterky, Alesia Tietze, Anetta Härtlova, Anders Ståhlberg, Ka-Wei Tang, Volkan Sayin, Bright Nwaru, Lars Rokkjær and Julia Grönros is taking photo) were amazing. We have learnt a lot about our personal strengths and each other’s and of course there is always the room for improvement, we never stop learning.  Warm thanks to Cristina, Fredrik, Anetta, Anders, Ka-Wei, Volkan, Bright and Julia for succeeded training, to my research group (Ann, Birsen, Daniel, Hanna, Helal, Jenn, Karan, Luisa, Shitanshu) for honesty in giving feedback and WCMTM Directors (Christina Jern and Margit Mahlapuu) for giving us an opportunity to participate.

December 2021 - I am proud to announce that AMiLion Technology has been launched. Cost effective and user-friendly technology platform enabling improved analytical precision. The first technology platform that can measure levels of bioavailable copper with high precision. Direct measurement of free copper in serum or plasma has the potential to provide a unique tool for the screening, diagnosis, and monitoring of diseases e.g. Alzheimers disease(AD), Menkes and Wilsons Disease.

20/12/2021 - another project has been awarded ‘Verification for Utilization’ (VFT) funding from the Grants and Innovation Office (FIK) in order to utilize our research in the area of antimicrobial peptides. VFT is a Vinnova funded program that aims to enable utilization of research from Swedish universities. VFT financing is used to investigate how academic research can be utilized and made available and useful for the general public. It can give insights into potentially relevant collaboration partners within and outside academia. Are you also interested in utilization? Read more and express your interest here: VFT program GU.

September 2021 - Warm welcome new members to our team Anna (Bachelor Thesis) focuses on bioinspired nanopores project, Patrick (Internship) focuses on synthesis of special amino acid building blocks, Hawa (Master Thesis) is focusing on development of Sortase A peptide inhibitors, and Birsen (Master Thesis) - transmembrane peptides project.

08/09/2021 - Alesia is promoted to Senior Lecturer in Medicinal Chemistry at the Faculty of Science/University of Gothenburg

26/01/2021 - Alesia is awarded Docentship in Medicinal Chemistry at the Faculty of Science/ University of Gothenburg, now she is an Associate    Professor in Medicinal Chemistry

01/2021 - Alesia is elected to department council at the Department of Chemistry and Molecular Biology/ UGOT

01/2021 - gratulations to Andreas, our paper on NCL of hydrophobic peptides is now online at Journal of Organic Chemistry

2020

12/2020 - our innovation Biosense project has been awarded with GU Innovation VFT+ Funds (SEK 400,000). Biosense was selected to receive Vinnova’s VFT+ funds managed by GU Innovation for verification activities towards partners, customers and investors.

10/2020 - Alesia awarded with prestigious Swedish Research Council Starting Grant 2021-24 (SEK 3,8 Mio.)

10/2020 - Alesia was inaugurated to the Early Career Advisory Board of Chemistry - A European Journal

09/2020 - Shitanshu joined our group as PhD student, his project focuses on engineering of bioinspired nanopores

08/2020 - Warm welcome to our new members, Karan and Luisa, who are starting their projects as master students. Karan will focus on structure-activity relationship studies of toxins and Luisa on antimicrobial peptides (CARe project)

07/2020 - Welcome Helal and Farnaz! They joined our group starting PhD project and Master Thesis respectively

09/04/2020 - Gratulations to Andreas! He defended his Dissertation in Darmstadt!

March 2020 -  2 PhD positions are available in our group (deadline for applications is expired).

28/02/2020 - Gratulations to Lena! She defended her Dissertation in Darmstadt!

January 2020 We received co-financial support from our CMB department for PhD position in our project "Design and Synthesis of Switchable Peptide-based Nanopores"

January 2020 We received funding from  Centre for Anthibiotic Resistance Research (CARe) research proposals call 2020-2022 for our research grant proposal "Genome-based natural product discovery: Characterization of bioactive compounds in marine Actinobacteria", collaboration with Carl-Johan Wallentin (CMB, GU), Edward Moore (Sahlgrenska Academy/GU), Roger Karlsson  (Sahlgrenska University Hospital) and Beatriz Cámara (Federico Santa María University/ Valparaíso, Chile

2019

25-26/09/2019 Lena is representing our group at the last iNAPO retreat with a talk in Graselenbaach

25-26/09/2019 Alesia is joining 2nd Swedish Medicinal Chemistry Symposium in Stockholm as invited speaker

19-20/09/2019 our team was participating at WCMTM (Wallenberg Centre of Molecular and Translational Medicine) Kick-off on September 19-20 2019

09/2019 warm welcome to Helal who joined our group for Master Thesis within the project of development of peptide-based antivirulence compounds

08/2019 Back from the official visit of Belgorod National Research University/ Belgorod/ Russia after successful measurements of delivered peptides and project discussions

from left to right: Dr. Michail Korokin (docent of Pharmacology and Clinical Pharmacology Department), Dr. Daniel Tietze, Alesia, Prof. Igor Konstantinov (Vice Rector of science), Prof. Michael Pokrovskii (head of the institute of pharmacology on living organisms)

06/2019 Welcome to new team members Hanna, Jie both as PostDocs and Daniel as Researcher in our lab

30/05/2019 finally our lab moved from Darmstadt to Gothenburg! Thank to all who helped us to pack and unpack, special thanks to Lena, Andreas, Ivana, Jie, Hanna and Daniel as well as the moving company to safe and in-time delivery.

January 2019  Postdoc positions are available in our group: Deadline 17/01/2019.

12/2018 LOEWE Project "iNAPO - Ion-conducting nanopores" will be prolonged for a final funding period relied on media report (with Lena's foto on the cover page)

10/2018 Alesia has accepted an appointment as Associate Senior Lecturer in Medicinal Chemistry at Wallenberg Centre for Molecular and Translational Medicine, Department of Chemistry and Molecular Biology at the University of Gothenburg, Göteborg, Sweden and received generous career package from Wallenberg Centre for Molecular and Translational Medicine (ca. SEK 22 Mio.)

09/2018  Poster Prize at the 35th European Peptide Symposium in Dublin, Ireland Our lab’s research on membrane proteins and the development of a conjugation strategy towards quantitative synthesis of these structures gained great interest at the 35th EPS 27.08-31.08.2018 in Dublin, Ireland. Lena was awarded one of the three Wiley Poster Prizes (200 €) for her poster presentation, congratulations! 

07/2018  Gratulations to Lena! She won „Best Talk Award“ at the PhD student day of the chemistry department of the TU Darmstadt on June 28th

01/2018  Our new manuscript about the synthesis of membrane proteins has been accepted for Publishing in Chemical Science: Chemical synthesis of membrane proteins by native chemical ligation: a model study on the influenza virus B proton channel, Baumruck, A. C., Tietze, D., Steinacker, L. K., Tietze A. A.*, 2018, DOI: 10.1039/C8SC00004B 

06/2017  Our new manuscript about some intriguing properties of ILs has just been accepted for publishing in JOC: Reactions of sulfur-containing organic compounds and peptides in 1-ethyl-3-methyl-imidazolium acetate, Baumruck, A. C.,Tietze, D., Stark, A.; Tietze, A. A.*“

03/2017  Alesia is appointed as TU Darmstadt Athene Young Investigator

02/2017  Andreas was a selected participant at the Winter School on Ionic Liquids (within COST CM1206) on February 7 – 10, 2017 in Porto, Portugal. The main goal of this school was to deliver a cross-disciplinary learning approach and condensed overview in the field of ionic liquids with emphasis on State of the Art, R&D methodologies, functionalities and applications. The lectures were problem-solving oriented emphasizing case studies of relevance to properties, characteristics of the ionic liquids and are specially geared towards novice scientists in the ILs field.

12/2016  Subtype-specfic block of voltage-gated K+ channels by µ-conopeptides, Biochemical and Biophysical Research Communications, is accepted for publication

07/2016  We warmly welcome our new PhD studentLena Steinacker to our research group!  06/2016  Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels, BBA General Subjects, is published

05/2016  Positive Evaluation of the Liebig-Fellowship. It is prolonged for the next funding period

01/2016  We are participating in the LOEWE Program for Scientific and Economic Excellence “iNAPO” (Ion-conducting Nanopores)

OUR GROUP IS SPONSORED BY: