Chemical synthesis of bioactive peptides &  membrane-associated proteins: from drug discovery to bioinspired materials



23. Müller, L.K.#, Duznovic, I.#, Tietze, D., Weber, W., Ali, M., Stein, V., Ensinger, W., Tietze, A. A. Ultrasensitive and selective copper (II) detection: introducing a bioinspired and robust sensor (2020), Chem. Eur. J., doi: 10.1002/chem.202001160 

22. Müller, L. K., Baumruck, A. C., Zhdanova, H., Tietze, A. A., Challenges and perspectives in chemical synthesis of highly hydrophobic peptides (2020), Front. Bioeng. Biotechnol., doi: 10.3389/fbioe.2020.00162


21. Korokin, M. V., Soldatov, V. O., Tietze, A. A., Golubev, I. V., Kubekina, M. V., Puchenkova, O. A., Denisyuk, T. A., Gureyev, V. V., Pokrovskaya, T. G., Gudyrev, O. S., Zhuchenko, M. A., Zatolokina, Pokrovskiy, M. V. 11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats (2019), Pharmacy & Pharmacology, 7(6):312-320. (In Russ.)                                                 doi:10.19163/2307-9266-2019-7-6-312-320

20. Tietze, D.*, Batzer-Kaufmann, D., Tietze, A. A., Voll, A., Reher, R., Koenig, G. M., Hausch, F. Structural and dynamical basis of G protein inhibition by YM-254890 and FR900359: an inhibitor in action (2019), J. Chem. Inf. Model., DOI: 10.1021/acs.jcim.9b00433

19. Schöttner, S., Brodrecht, M., Uhlein, E., Dietz, C., Breitzke, H., Tietze, A. A., Buntkowsky, G. and Gallei, M. Amine-containing block copolymers for the bottom-up preparation offunctional porous membranes (2019), Macromolecules, 52, 7, 2631-2641

18. Kaufmann, D. , Tietze, A. A., Tietze, D. In Silico Analysis of the Subtype Selective Blockage of KCNA Ion Channels through the micro-Conotoxins PIIIA, SIIIA, and GIIIA (2019), Marine Drugs, 17

17. Tietze, D.*, Koley Seth, B., Brauser, M., Tietze, A. A., Buntkowsky, G.*, Ni II complex formation and protonation states at the active site of a nickel superoxide dismutase-derived metallopeptide: implications for the mechanism of superoxide degradation (2018), Chemistry,  24, 15879-15888

16. Heimer, P., Tietze, A. A., Bäuml, C. A., Resemann, A., Mayer, F. J., Suckau, D., Ohlenschläger, O., Tietze, D.*, Imhof, D.*, Conformational µ-conotoxin PIIIA isomers revisited: The impact of cysteine pairing on disulfide bond assignment and structure elucidation (2018), Anal. Chem., 90(5), 3321-3327

15. Baumruck, A. C., Tietze, D., Steinacker, L. K., Tietze A. A.*., Chemical synthesis of membrane proteins by native chemical ligation: a model study on the influenza virus B proton channel (2018), Chem. Sci., 9, 2365-2375

14. Leipold, E., Ullrich, F., Thiele, M., Tietze, A. A., Terlau, H., Imhof, D., Heinemann, S. H., Subtype-specific block of voltage-gated K+ channels by μ-conopeptides (2017), Biochem. Biophys. Res. Commun, 482 (4), 1135-1140.

13. Baumruck, A. C., Tietze, D., Stark, A., Tietze, A. A., Reactions of Sulfur-Containing Organic Compounds and Peptides in 1-Ethyl-3-methyl-imidazolium Acetate (2017), J. Org. Chem., 82 (14), 7538–7545 

12. Tietze, D.#, Leipold, E.#, Heimer, P., Böhm, M., Winschel, W., Imhof, D., Heinemann, S.H., and Tietze, A.A.*, Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels, (2016), BBA Gen. Sub., 1860, 2053-2063

11. Culbertson, A.#, Tietze, A. A.#, Tietze, D., Chou, Y.-H., Smith, A. L., Cook, M. D., Young, Z.T., Zabotina, O. A.*, Homology model of a Xyloglucan Xylosyltransferase 2 reveals critical amino acids involved in substrate binding (2016), Glycobiology, 26(9), 961-972

10. Culbertson, A. T., Chou, Y.-H., Smith, A.L., Young, Z.T., Tietze, A. A., Cottaz, S., Faure, R., Zabotina, O.A.*, Enzymatic Activity of Arabidopsis Xyloglucan Xylosyltransferase 5 (2016), Plant Physiol., 171(3), 1893-904

9. Heimer, P.#, Tietze, A.A.#, Böhm, M.#, Giernoth, R., Kuchenbuch, A., Stark, A., Leipold, E., Heinemann, S.H., Kandt, C., Imhof, D.* Application of room temperature aprotic and protic ionic liquids for exidative folding of cysteine-rich peptides (2015), Chem. Biol. Chem. 15, 18, 2754–2765  

8. Böhm, M.#, Tietze, A.A.#, Heimer, P.#, Chen, M., Imhof, D.* Ionic liquids as reaction media for oxidative folding and native chemical ligation of cysteine-containing peptides (2014), J. Mol. Liquids, 192, 67-70  

7. Tietze, A.A.*, Bordusa, F., Giernoth, R., Imhof, D., Lenzer, T., Mrestani-Klaus, C., Neundorf, I., Oum, K., Reith, D., Stark, A., On the nature of interactions between ionic liquids and small amino acid-based biomolecules (2013), Chem. Phys. Chem., 14(18), 4044-64  

6. Tietze, A.A., Tietze, D., Ohlenschläger, O., Leipold, E., Ullrich, F., Mischo, A., Buntkowsky, G., Görlach, M., Heinemann, S. H., Imhof, D.*, The one and only fold? Structurally diverse µ-conotoxin PIIIA isomers block sodium channel NaV1.4 (2012), Angew. Chem. Int. Ed., 51 (17), 4058-4061

5. Tietze, A.A.*, Heimer, P., Stark, A., Imhof, D., Ionic liquid applications in peptide chemistry: synthesis, purification and analytical characterization processes (2012), Molecules, 17(4), 4158-4185  

4. Miloslavina, A.A., Ebert, C., Tietze, D., Ohlenschläger, O., Englert, C., Görlach, M., Imhof, D.*, An Unusual Peptide from Conus villepinii: Synthesis, Solution Structure, and Cardioactivity (2010), Peptides, 31, 1292-1300

3. Leipold, E., Markgraf, R., Miloslavina A. A., Kijas M., Schirmeyer, J., Imhof D., Heinemann S. H.*, Molecular determinant for the subtype specificity of µ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels (2010), Neuropharm., 61 (1-2), 105-111  

2. Miloslavina, A.A., Leipold E., Kijas M., Stark A., Heinemann S.H., Imhof D.* A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides (2009), J. Pept. Sci., 15(2), 72-77  

1. Gotfriedsen, J., Miloslavina, A.A., Edelmann, F. T.*, Cyclooctatetraene made easy (2004), Tetrahedr. Lett., 45, 3583-35